Ojective Myocardial infarction is associated with an increased incidence of atrial fibrillation in patients with chronic myocardial infarction, independent of heart failure and hypertension. Although it is known that left ventricular myocardial infarction increases atrial fibrillation vulnerability, potential substrates for altered atrial fibrillation vulnerability knows poorly. The purpose of the present study was to observe the changes of action potential and ion channels in isolated atrial myocytes after left ventricular myocardial infarction. Methods Twenty rabbits were randomly divided into two groups: control group (n=10, thoracotomy, left anterior descending artery not ligated)